Patriarch of Antioch (449-455). After the deposition of Domnus II, patriarch of Antioch, by the second Council of Ephesus, AD 449, Dioscorus of Alexandria asked the emperor Theodosius II to fill the vacancy of the See of Antioch with one of the clergy. Maximus was selected by the council and installed by Anatolius Patriarch of Constantinople. The elevation of Maximus gained a positive reputation in the conduct of his diocese and province. He deposed all Nestorian bishops those consecrated by Dumnos II. And condemned both Nestorius and Eutyches. He attended the Council of Chalcedon in October 451, and took his seat as Patriarch of Antioch, and a special exception was made of the substitution of Maximus for Domnus, and the bishop of Rome had opened communion with him.

Maximus next appears in a letter, dated June 11, 453, from Leo of Rpme, to whom he had appealed in defense of the prerogatives of his See. Leo promised to help him against either Jerusalem or Constantinople, exhorting him to assert his privileges as bishop of See of Antioch. Maximus's zeal for the orthodox faith was well known, to maintain the doctrine founded by St. Peter in the cities of Antioch, against the erroneous teaching both of Nestorius and Eutyches, and to watch over the churches of the East generally.

Two years later, 455, Maximos abdicated and the Chalcedonians seized control over the See of Antioch and appointed the following Patriarchs: Basil 456-458, Acacius (Aqaq) 458-461, Martyrius 461-465. We do not know how much longer he lived or what became of him.