Bishop of Antioch (260-272), He was certainly born farther east at Samosata (At present the ruins of Samosata may be seen at Samsat on the right bank of the Euphrates), and may have owed his promotion in the Church to Zenobia, queen of Palmyra. Several synods, probably three, were held against him about 264-66-68. St. Dionysius of Alexandria had desired to attend the first of these, but was prevented by his infirmities. Firmilian of Cæsarea, St. Gregory Thaumaturgus, his brother Athenodorus, and many others, were present. Paul held the civil office of Procurator ducenarius, and was protected by Zenobia, the famous Queen of Palmyra. He was a wealthy man, and had many obsequious followers among neighboring bishops. Many defended his doctrine, and he declared himself orthodox. In the first meetings the bishops were satisfied. At another Paul was condemned, but promised to retract his errors. This he failed to do. A final council was summoned. Firmilian died on the way to it. The principal part was taken by a priest of Antioch, Malchion, who was an accomplished man of letters and head of the school of Greek literature at Antioch, in disputation with Paul he plainly convicted him of heresy, and procured his deposition. A letter written by Malchion in the name of the synod and addressed to bishop Dionysius of Rome, and bishop Maximus of Alexandria, respectively bishops of Holy See of Antioch, with priests and deacons, who attended a synod at Antioch in 268/9 and deposed Paul

The letter just mentioned is the only indisputably contemporary document concerning him, has been preserved by Eusebius in part; a few fragments only remain of the shorthand report of the disputation. The letter accuses Paul of acquiring great wealth by illicit means, of showing haughtiness and worldliness, of having set up for himself a lofty pulpit in the church, and of insulting those who did not applaud him and wave their handkerchiefs, and so forth.

Their sentence, however, did not take effect and Paul could not be driven from his See until late in 272, when the emperor Aurelian took possession of Antioch in 272. having defeated Zenobia and anxious to impose upon Syria the dogmatic system fashionable in Rome, deposed Paul and allowed the rival candidate Domnus to take his place and emoluments. Thus it was a pagan emperor who in this momentous dispute ultimately determined what was orthodox and what was not; and the advanced Christology to which he gave his preference has ever since been upheld as the official orthodoxy of the Church.

Paul was driven out in utter disgrace by the civil power. Of his life no more is known to us. His doctrine was akin to the dynamistic Monarchianism of Theodoltus, and he was nicknamed a follower of Artemas. We can gather these points: the Father, Son, and Holy Ghost are but a single Person (prosopon). The Son or Logos is without hypostasis, being merely the wisdom and science of God, which is in Him as reason is in a man. Before all worlds He was born as Son (Logos prophorikos) without a virgin; he is without shape and cannot be made visible to men. He worked in the Prophets, especially in Moses (let us remember that Zenobia was a Jews favorite, and that this monarchianism may have been intended to please her), and in a far higher way in the Son of David who was born by the Holy Spirit of a Virgin. The Christ, the Saviour, is essentially a man, but the Holy Spirit inspired Him from above. The Father and the Son are one God, whereas Christ is from the earth with a personality of his own. Thus there are two Persons in Christ. The Logos as Wisdom dwelt in the man Jesus, as we live in houses, and worked in Him as inspiration, teaching Him and being with Him, and was united with Him not substantially (or essentially, ousiodos), but qualitatively (kata poioteta). Mary did not bring forth the Word, for she did not exist before the worlds, but a man like to us. Paul denied the inference that there are two Sons. The Son of the Virgin is great by Wisdom, who dwelt in no other so.

Union of two Persons is possible only by agreement of will, issuing in unity of action, and originating by love. By this kind of union Christ had merit; He could have had none had the union been by nature. By the unchangeableness of His will He is like God, and was united to Him by remaining pure from sin. By striving and suffering He conquered the sin of our first parent, and was joined to God, being one with Him in intention and action. God worked in Him to do miracles in order to prove Him the Redeemer and Saviour of the race. By the ever growing and never ceasing movement of friendship He has joined Himself to God so that He can never be separated through all eternity, and His Name is above every Name as a reward of love. Judgment is made over to Him; He may be called "God from the Virgin", "God from Nazareth". He is said to have pre-existed, but this means by predestination only. The baptism of Christ, as usual was regarded by Paul as a step in His junction with the Logos. If He had been God by nature, Paul argued, there would be two Gods. He forbade hymns to Christ, and openly attacked the older (Alexandrian) interpretations of Scripture.

Scholars will pay little heed to the charges of rapacity, extortion, pomp and luxury made against Paul by the authors of this letter. It also accuses him not only of consorting himself with two "sisters" of mature age and fair to look upon; but of allowing his priests and deacons also to contract platonic unions with Christian ladies. No actual lapses however from chastity are alleged, and it is only complained that suspicions were aroused, apparently among the pagans.

The party of Paul did not at once disappear. The Council of Nicæa declared the baptism conferred by the Paulianists to be invalid. There is something, though not much, of his teaching in the Lucianist and Arian systems which issued from Antioch. But their Christology was the very opposite of his, which was rather to reappear in a modified form in Theodore of Mopsuestia, Diodorus, Nestorius, and even Theodoret, though these later Antiochenes warmly rejected the imputation of any agreement with the heretic Paul, even in Christology.